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KMID : 0350519920450010299
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Journal of Catholic Medical College
1992 Volume.45 No. 1 p.299 ~ p.306
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Thyrotropin Releasing Hormone Stimulation Test and Its Relationship to Clinical Features Assessed by Several Self-rating Clinical Scales in Major Depressives and Schizophrenics
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Abstract
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It has been known that the blunted thyroid stimulating hormone(TSH) response to thyrotropin releasing hormone(TRH) is related with the clinical features of major depressives and schizophrenics.
Therefore, for the purpose of evaluating the relationship of clinical features in major depressives and schizophrenics to TRH stimulation test, the authors assessed four self-rating clinical scales(Self-rating anxiety acale, Zung's depression
scale,
Schalling-Sifneos personality scale and Torontoalexithymia scale) and TSH reponse to TRH stimulation.
The subjects consisted of 26 major depressives(11 males and 15 females) and 21 schizophrenics(8 males and 13 females) who had not taken any psychotropic drugs for at least 2 weeks.
@ES The results were as follows;
@EN 1. There were no significant differences in frequency rate of the blunted TSH response to TRH stimulation in major depressives(65.4%)and schizophrenics(57.1%).
2. There were significant differences in mean score of self-rating anxiety scale in major depressives(39.62*7.29) and schizophrenics(35.29*6.75)(P=0.04).
3. There were significant differences in mean score of Toronto alexithymia scale in blunted TSH group(80.42*9.17) and non-blunted TSH group(69.22*17.31) of all patients(P=0.02).
4. There were no significant differences in mean score of each scale in blunted TSH group and non-blunted TSH group of major depressives.
5. There were differences in mean score of Toronto alexithymia scale in blunted TSH group(80.75*8.83) and non-blunted TSH group(68.00*17.93) of schizophrenics.
6. In all patients, values of △TSH correlated inversely with the scores of Toronto alexithymia acale(r=-0.29, P=0.05).
In light of these results, it is likely that the more blunted in TSH responses to TRH stimulation, the higher scores of alexthymia in major depressives and schizophrenics were noted.
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